Background: Noise and crowdingare the most stressful factors for human beings. Study aimed to clarify their effect on cortisol, ACTH, epinephrine, insulin and the amelioration effect of Sulpiride. Material and Methods: Thirty six female rats were divided into six groups (6/each): 1- Rats served ascontrol, 2- Rats treated with Sulpiride drug, 3- Rats exposed to noise (90db, 3hr. per day) for 45 days. 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed to crowding. 6- Rats exposed to noise and treated with Sulpiride drug. Results: Noise and crowding stresses caused a significant increase of cortisol, ACTH and epinephrine while there was a significant decrease in insulin hormone. Sulpiride drug   ameliorated these parameters. Conclusion: it is useful to use Sulpiride drug with   people who are exposing to noise and  crowding stress.