Bachground: The nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently used medications worldwide for the treatment of a variety of common chronic and acute inflammatory conditions. The association between NSAIDs and liver disease is poorly documented. Aim: the current study was carried out to investigate the hepatic disorders associated with prolonged use of Brufen drug and evaluate the role of both moringa and dandelion extracts as hepatoprotective agents against these disorders. Methods: rats were divided into six groups (six rats/ each) as follow: group 1: rats did not receive any treatment and  served as control;      group 2 : rats orally administrated moringa extract (300mg/kg b.wt) daily for 12 weeks; group 3: rats orally administrated dandelion extract (300mg/kg b.wt) daily for 12 weeks ; group 4: rats orally administrated Brufen (18mg/kg b.wt) daily for 12 weeks;.group5: rats orally administrated moringa extract (300mg/kg b.wt) daily for one week alone then concomitant with Brufen (18mg/kg b.wt) for 11 weeks ;group 6: rats orally administrated dandelion extract (300mg/kg b.wt) daily for one week alone then concomitant with Brufen (18mg/kg b.wt) for 11 weeks.Results: the present results showed that the administration of Brufen led to significant increases in the levels of TL, TC, TG, LDL-C, ALT, AST, ALP, GGT, MDA and XO. While significant decreases in HDL-C, TP, ALP, GSH, TAC, SOD, CAT and GSH-Px, were recorded in Brufen treated rats group. On the other hand, the administration moringa or dandelion extracts succeeded to alleviate these abnormalities resulted from Brufen drug as indicated by the clear amelioration of occurred hepatic metabolic disorders, oxidative stress and histopathological changes in addition to improvement of the antioxidant status. Conclusion: it could be concluded that moringa or dandelion extracts have a remarkable role in management the hepatic disorders and oxidative stress associated with prolonged use of Brufen. Additionally it was recorded that moringa extract was more beneficial than dandelion extract in alleviating the occurred adverse effects of Brufen.