Background: The study on the natural herbal contraception has become one of the main interests of modern contraceptive studies. Herbs have been used by women since the beginning of time in an attempt to control their fertility. The development of new fertility regulating drugs derived from medicinal plants is an attractive proposition, Aloe Vera is a durable plant belonging to Sousanian family. Aim of the work: This work was assessed to evaluate the probable contraceptive effect of the aqueous extract of Aloe vera plant and its effect on the some vital organs in the female albino rats. Materials and Methods: This study was performed on twenty female albino rats with an average 120-140g body weight. The animals were divided into two groups (5 /cage); Group I (Control untreated group) and Group II (Aloe vera group that supplied orally with 7 mg/kg body wt/day of the plant extract for 30 ± 2 days).Results A prolonged proestrus and estrus phases of the estrous cycle were observed in the Aloe  vera group .The mean serum level of estrogen (estradiol) was significantly increased in the Aloe  vera group as compared to the control group (P<0.01) while non significant difference was found for serum level of progesterone and the tumor markers, CA15-3 and CA-125.The results also showed a marked decline (p<0.01) in levels of the serum calcium, creatinine, urea, total proteins, albumin, globulin and ratio of TC/HDL accompanied with a marked elevation (p<0.01) in the serum phosphorus, total lipid, TC, TG, HDL and LDL levels in the Aloe  vera group in comparison with those of control group. However, levels of uric acid, AST, ALT, GGT, VLDL and ratios of LDL/HDL (risk factors) and A/G were approximately as that of the control group. Conclusion: It could be concluded that Aloe vera can be used as a contraceptive drug that can increase the estrogen level due to its phytoestrogen components such as beta sitosterol and without deleterious effects on the other vital organ ( liver and kidney), however it's use is to be restricted with women suffering from low ca++level as well as osteoporosis.