Background and aim of the work: Therapeutic uniportal video-assisted thoracic surgery (VATS) has less postoperative pain, shorter hospital stay, and less operative time. In this study we will present our experience in therapeutic VATS at King Abdul Aziz Specialist Hospital, Taif Saudi Arabia.  Patients and methods: This retrospective study was conducted in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia, from July 2012 to January 2016 and included 162 patients who were admitted to the hospital in this period and therapeutic uniportal VATS was conducted for them. Results: The 162 patients were 102 males (63%) and 60 females with mean age of 45.1±6.8years. Bilateral sympathectomy was performed for palmar hyperhidrosis in 36% of cases, VATS stapled blebectomy with apical pleurectomy were performed for primary spontaneous pneumothorax in 32% of cases, wedge resections in 23.5%, adhesiolysis was performed in 5%, and in3.7% anatomical segment resections was done. Mean operative time was 25.5±5.5 minutes. The mean hospital stay was 5.3±1.2 days. No operative or early postoperative mortality was recorded.  Conclusion: Uniportal VATS was proved to be safe and effective and can replace the multiportal approach in the management of various disorders which require thoracic surgery.