Background and aim of the work: laparoscopic sleeve gastrectomy (LSG) proved to be an effective operation for control of obesity and associated comorbidities. The aim of this study was to evaluate the impact of this operation on weight reduction, improvement of obesity comorbid diseases, and the quality of life (QoL).Patients and method: A cross sectional web-based survey was conducted between June and October 2016. A total of 660 patients who was subjected to LSG volunteered in the survey and answered the online questionnaire which consisted of 30 items (multiple choice and short answered questions). Results: the study involved 425male patients (64.4%) and 235 female patients (35.6%).  The mean preoperative BMI was significantly reduced from 38.6±9.1 kg/m² to 28.4±6.9kg/m² after a mean duration of 24±5.6 months following LSG. There was highly significant improvement (P< 0.001) in obesity comorbid diseases; however, the improvement was significant (P< 0.05) for improvement in sexual performance. The patient satisfaction from the weight reduction after LSG was rated as excellent by 68.2% of  participants, as very good to good by 24.2% of participants, and as just accepted by 1.8%.  5.8% of patients had no changes or even gain weight after LSA (P>0.05). 92.4% considered that their quality of life became better and would recommend the sleeve gastrectomy for other obese people who suffer from the obesity. Conclusion: laparoscopic sleeve gastrectomy is a good option for those with morbid obese patients as regard weight reduction, improvement of obesity comorbid diseases, and their quality of life.