This report is point to patient admitted to our hospital as case of G6PD and dilated cardiomyopathy, with congestive heart failure started on anti-failure and aspirin and need to be admitted on ICU for inotropic support, then on the 2^nd day the patient developed thrombocytopenia then we stopped aspirin and warfarin started after using of warfarin by one-day patient developed sever thrombocytosis so we consider to start low molecular heparin which improved the platelets count then started to decreased to normal range in 5 days duration after LMH started.