Objective: Oxidative stress is induced by bisphenol A (BPA) and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA. Materials and methods: 30 female albino rats were divided into 3 groups (10/each); group1: control rats, group 2: rats treated with bisphenol A (20 mg/ kg.B.wt) for three months, and group 3: rats treated with bisphenol A (20 mg/kg.B.wt) for three months, then treated with BPA and vitamin E (0.57/100 g B.wt) for other 15 days. Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters. Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent.