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14988

Ameliorative Effect of Olive Leaf Extract on the Fetal Lung Tissue of Diabetic Pregnant Rats

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Last updated: 24 Dec 2024

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Abstract

Aim of the work- Diabetes mellitus is a common metabolic disease not only affecting the individual, but also imposes adverse effects on the offsprings. Besides increasing congenital malformations, maternal diabetes is suggested to be associated with early pregnancy loss, altered sex ratio in the offspring and long-term postnatal diseases. Antidiabetic plants are used as supportive therapy in the treatment of diabetes during pregnancy, so the present study aims to investigate the protective effect of olive leaf extract on the fetal lung of the diabetic pregnant rats. Material and methods - Forty pregnant albino rats were used and categorized after mating into four groups; group 1: control group(C), group 2: rats treated with olive leaf extract during the period of pregnancy (O) (1 ml/100gm. b. wt), group 3: streptozotocin induced diabetic rats (D)(STZ 35 mg/kg b.wt), group 4: diabetic rats treated with olive leaf extract (D+O) (as in groups 2&3). The pregnant females of different groups were dissected during the 19 th day of pregnancy. Lung samples of fetuses were taken for the histological and histochemical studies.  Results- Histopathological and histochemical observations of fetal lung tissue showed that the olive leaf extract succeeded to minimize the drastic changes which were observed in the fetal lung of diabetic rats. Conclusion- It is recommended that the use of the olive leaf extract has the ability to minimize the adverse effects in the fetal lung tissue of diabetic rats.    

DOI

10.12816/0018769

Keywords

Pregnant diabetic rats, olive leaf extract, fetus, lung, hyperglycemia

Authors

First Name

Mervat A.

Last Name

Abd Rabou

MiddleName

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Affiliation

Biology Department, Faculty of Science, Al-Jouf University, Saudi Arabia

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First Name

Fawzya A.

Last Name

Al-Ghamdi

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Abdul-Aziz University, Saudi Arabia

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Orcid

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First Name

Nehal A.

Last Name

Abu Elnaga

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Cairo

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Orcid

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Volume

61

Article Issue

1

Related Issue

3110

Issue Date

2015-10-01

Receive Date

2018-09-27

Publish Date

2018-09-27

Page Start

670

Page End

684

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_14988.html

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https://ejhm.journals.ekb.eg/service?article_code=14988

Order

42

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Ameliorative Effect of Olive Leaf Extract on the Fetal Lung Tissue of Diabetic Pregnant Rats

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Article

Created At

22 Jan 2023