Aim of the work-In Egypt cervical carcinoma is ranked as a number 6 of all malignant tumors. There is growing evidence that the human papillomavirus (HPV) is associated with the development of cervical cancer. Patients and Methods-The present study hunted HPV in Egyptian biopsies of cervical cancer by using in situ hybridization (ISH) technique .Light microscopy and ultra-structural features accompanied by squamous cell carcinoma (SCC) of the cervix were monitored. Results-The ultra structural study revealed viral particles in some epithelial cell nuclei and cytoplasm in the moderately-differentiated squamous cell carcinoma. These were suggested to be Herpes Simplex Virus (HSV). Conclusion-The potential relation between HPV and HSV in the incidence of Cervical Squamous Cell Carcinoma is discussed.