Background: genital Herpes infection is caused by HSV 1 and HSV2 Virus. It causes distressing symptoms in a significant number of adolescents and adults with over 40 million people sufferers from recurrent HSV genital ulcer disease causes significant disease globally and it is potentially fatal when transmitted to neonates and most maternal infections with risk of transmission are asymptomatic. Aim of the Study: highlighting the crucial rule of parents' education and awareness on the prevention and management of HSV in neonates (NHSV). Patients and methods: 112 females and 34 males HSV2 seropositive patients were assigned to fill a questionnaire on their awareness about HSV2 infection and symptoms and its effect on potential neonates. In parallel, there was a questionnaire for the assigned gynecologists to assess the counseling process of the mothers about the history of previous infection. Data was compared to the patients' medical chart and past delivery of defected and treated neonates. Results: Patients whom were aware with the dangerous effect of the infection of virus had no mortality in their neonatal and had the good treatment for them. Conclusion: Couple educational and Awareness campaigns on genital Herpes infection have become a compelling need in order to avoid neonates mortality and help in designing preventive measures for neonates morbidity.