Aim of the work: gastritis is the inflammation of the lining of the stomach .It is caused by many factors like infection by Helicobacter pylori, drug induced such as aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), corticosteroids and alcohol consumption. Pantoprazole prevents HCL formation by blocking proton pumps in parietal cells of the stomach leading to stoppage of pepsinogen enzyme activation. Rebamipidestimulates prostaglandins synthesis so the mucous barrier can be build up to protect the gastric mucosa, so this study aimed to evaluate the efficacy of Pantoprazole and Rebamipide on stomach mucosa protection from the gastritis that was induced by Dexamethasone in rats. Material and methods: twenty-five male senile albino rats were included in this study and divided into five groups: G1 (Control group), G2 (Dexamethasone administrated group), G3 (Pantoprazole administrated group), G4 (Rebamipide administrated group) and G5 (Pantoprazole and Rebamipide administrated group). The collected stomach specimens were subjected to hematoxylin and eosin, PAS and alcian blue stains. Results: the most weight loss was detected in Dexamethasone administrated group, while the least weight loss was realized in dexamethasone and Rebamipide administrated group. Gastric samples showed improvement in gastric mucosa in G3 and G4, but the best improvement was demonstrated in G3. Conclusion: Rebamipide has a better protective effect than the Pantoprazole in prevention of gastric mucosal injuries.