Background: Obesity is a disabling disease which has gained greater attention worldwide. It significantly increases the risk for other diseases such as insulin independent diabetes mellitus also known as diabetes type 2. The most common surgical procedure for obesity is liposuction. It is traditionally performed either as small-volume liposuction or large-volume liposuction. Aim of the Work: to spot the light on the effect of large volume liposuction on fasting insulin level changes after 3 months postoperative and to find if LVL may obtain any improvement in metabolic variables. This study will provide the clinician with a more valid basis on which to advise patients undergoing body-contouring procedures, particularly to ensure realistic expectations regarding the effects of body-reshaping procedures on general health. Patients and Mehtods: This is prospective study was conducted on a total of 15 overweight and obese (BMI 26–35 kg/m²) premenopausal women (age 21–40years). All subjects were at their maximum body weight and weight stable for at least 3 months. The study took place at Ain Shams University Hospitals and other authorized hospitals under supervision of thesis supervisors studying fasting insulin changes after 3 months following large volume liposuction. Results: The present study demonstrates that large-volume abdominal liposuction should, by itself, be considered a clinical therapy for obesity and its metabolic sequelae. Aspiration of large amounts of subcutaneous abdominal fat in women with abdominal obesity, besides having cosmetic benefits, does significantly improve fasting insulin levels. Therefore, the procedure is safe and could successfully help obese subjects to reduce their potential metabolic risks.Conclusion: The analysis of the study suggests that plastic surgery could play a role in metabolism.  The surgical removal of fat is not detrimental with regard to variation of metabolic indices.