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12785

Correlation between Vitamin D Deficiency and Depression

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Last updated: 24 Dec 2024

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Abstract

Aim of the Study: To conduct a systematic review and meta-analysis of prospective cohort studies of the association of vitamin D deficiency with onset of depression in non- depressed individuals. Methods: A systematic review of the electronically searched publications of the scientific literature. We searched the Cochrane Hepato Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE (1946 to 2017), EMBASE (1974 to 2017), and Science Citation Index Expanded (1900 to 2017).  Initially all randomized clinical trials which studied the correlation of Vitamin D with depression were included, articles were then selectively screened according to the eligibility criteria. Results: the search yielded 11 studies, A meta-analysis of all studies without flaws demonstrated a statistically significant improvement in depression with Vitamin D supplements (+0.72 CI +0.28, +1.31). Nevertheless, studies with biological flaws were mainly inconclusive Conclusion: Our analyses are consistent with the hypothesis that Vitamin D supplementation (≥800 I.U. daily) was supported in the management of depression.  

DOI

10.12816/0042865

Keywords

depression, biological plausibility, Meta-Analysis, systematic review, 25OHD, Vitamin D supplementation

Authors

First Name

Afnan Hedian

Last Name

Alsofyani

MiddleName

-

Affiliation

Taif University

Email

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City

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Orcid

-

First Name

Abeer Mohammed M

Last Name

Alharbi

MiddleName

-

Affiliation

Alfaisal University

Email

-

City

-

Orcid

-

First Name

Arwa Bader N

Last Name

Alanazi

MiddleName

-

Affiliation

Northern Border University

Email

-

City

-

Orcid

-

First Name

Khaled Abdul Aziz

Last Name

Alasous

MiddleName

-

Affiliation

Sattam Bin Abdulaziz University

Email

-

City

-

Orcid

-

First Name

Rawan Ahmad

Last Name

Ageeli

MiddleName

-

Affiliation

Jazan University

Email

-

City

-

Orcid

-

First Name

Amirah Abduallah M

Last Name

ALZahrani

MiddleName

-

Affiliation

King Abdullaziz Hospital

Email

-

City

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Orcid

-

First Name

Moatez Khalaf

Last Name

Almofarreh

MiddleName

-

Affiliation

Aljouf University

Email

-

City

-

Orcid

-

First Name

Reham Awdah

Last Name

Albalwi

MiddleName

-

Affiliation

Tabuk University

Email

-

City

-

Orcid

-

First Name

Samirah Nasser A

Last Name

Majrshi

MiddleName

-

Affiliation

Primary Health Care Al-Jumum- Makkah

Email

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City

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Orcid

-

First Name

Muhannad Fahad W

Last Name

Alsahli

MiddleName

-

Affiliation

Al Imam Abdulrahman Al Faisal Hospital in Riyadh

Email

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City

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Orcid

-

First Name

Ayat Essam

Last Name

Shaban

MiddleName

-

Affiliation

Al Nahda Primary Health Care Center, Jeddah

Email

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City

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Orcid

-

First Name

Ghaida Mohammad

Last Name

Ahmad

MiddleName

-

Affiliation

East Jeddah Hospital

Email

-

City

-

Orcid

-

Volume

69

Article Issue

8

Related Issue

2381

Issue Date

2017-10-01

Receive Date

2018-09-06

Publish Date

2017-10-01

Page Start

3,134

Page End

3,143

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 69_Issue 8_Pages 3134-3143.pdf

PDF . 470.9kB

Link

https://ejhm.journals.ekb.eg/article_12785.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=12785

Order

28

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Correlation between Vitamin D Deficiency and Depression

Details

Type

Article

Created At

22 Jan 2023