Background: breast cancer, according to national cancer institute, is the most common site of cancer in women in Egypt as it accounts for about 38.8% of total malignancies among Egyptian females; it is an important cause of mortality among women. For many women with stage 1 or 2 breast cancer, the combination of partial mastectomy and radiation therapy – together referred to as breast- conserving therapy is preferable to total mastectomy because breast conserving surgery survival rates is equivalent to those after mastectomy while preserving the breast. Aim of the work: this study aimed to focus on the latero-central glandular pedicle technique as an oncoplastic procedure for management of medial breast cancer and to assess the technique clinically regarding oncological safety, surgical outcomes and patient satisfaction. Methods: this was a prospective analytical study that included 15 patients aiming to clinically assess the centro-lateral oncoplastic technique for both inner quadrants of breast cancer regarding oncological safety and patient satisfaction. This study was conducted at Ain-Shams University Hospitals. Approval of the Ethical Committee and written informed consent from all participants was obtained. Results: in our study we were able to conduct an excellent cosmetic outcome for a relatively large tumor excisions with 66% of the cases (10 patients) falling in excellent and very good score groups with mean cosmetic outcome score 4.26. Another 20% (3 cases) which fall in good and fair score groups as those two patients noticed asymmetry of the two breasts in front of the mirror as they refused bilateral breast reduction mastopexy. None of our cases have had a poor or an ugly score. Conclusion: the combination of plastic surgery techniques with breast oncology surgery gives the surgeon a new tool for treatment of breast cancer. This approach has enabled us to increase the number and extend the indications of breast conserving surgery with wider margins offering safer oncologic control with more satisfactory cosmetic outcome.