Background: proton pump inhibitors are agents that inhibit the final step in gastric acid formation. They are available in oral forms or intravenous forms. Proton pump inhibitors can be used in case of gastric ulcer. Antiplatelet therapy is a medication that acts as cardiovascular therapy as it is used in platelet inhibition. Some antiplatelet agents may case ulcer and proton pump inhibitors may become necessary for ulcer treatment, the use of this combination may cause adverse effects for patients. Aim of the work:  this study aimed to investigate the interaction between proton pump inhibitors and antiplatelet therapy. Materials and methods: we used the internet to obtain articles about this subject, we used  Google scholar, Pub Med and Research Gate to find the articles. Results: we obtained 44 articles, only 11 were included and we excluded 31 articles as they have either irrelevant title or content. Conclusion: interaction between proton pump inhibitors and antiplatelet therapy was conflicted. The data available were from randomized studies or trials, patients inclusion criteria, methods and outcome differ between the various studies, also the clinical data were limited.