Introduction: Diagnosis of schizophrenia is largely a clinical assessment of a group of signs and symptoms. There are various factors that can be a cause or a risk factor for creating this disorder; some preventable and some non-preventable. The treatment options are diverse and are continuously being studied in order to enhance results and minimize adverse effect of various forms of therapy. 
Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1987, through March 2017. The following search terms were used: schizophrenia, etiology of schizophrenia, pathophysiology, clinical features, and treatment of schizophrenia
Aim: Our aim in this study was to understand the etiology, pathophysiology, and study various lines and advancement in management of schizophrenia. Conclusion: In the recent years, many treatment options are emerging where newer drugs and their combination with or without non-pharmacological therapy have shown promising results. More studies must be done to implement advanced regimens for treatment of schizophrenia.