Background: Gallstone disease is common, and it is asymptomatic, patients may need an operative. Laparoscopic cholecystectomy becomes the choice for symptomatic gallstone disease intervention; open surgery was replaced by Laparoscopic cholecystectomy in the cholecystolithiasis treatment, open surgery has different complications. Laparoscopic cholecystectomy has several advantages over open surgery, but it has several complications also.                                                                                       Aim: To investigate the prevalence and risk factors of postoperative complications of open and lab cholecystectomy in AL-Madinahcitizen. Method: This retrospective cross-section study included 205 patients from king Fahad hospital in Al-Madinah AL-Munwwarah. A questionnaire was conducted on the participant by interview to investigate different variables. Results: The percent of a female was 73.7%, and percent of a male was 26.3%, the bleeding complication represented 19.5%, infection was 3.9%, biliary leakage was 3.9%, and wound infection was 1.5%. The mean duration of recovery was 3.56 days while the mean duration for returning back to work was 12.37 days. Lap operation had less duration for recovery than an open operation.                                                       Conclusion: Bleeding was the most common complication among patients, lap group patients experienced complications less than the open group. Male gender, age, obesity, the emergency of operation, diabetes mellitus, hypertension, thyroid and heart disease were not risked factors for complications.