Background: The goal of this study was to highlight the diagnostic methods and approaches toward most devastating cardiac disorders which are cardiac arrhythmias, MI and hypertensive. Methods: We searched thorough electronic databases as, MEDLINE, EMBASE using the following terms individually and/or in combination: ‘Cardiac arrhythmias', ‘myocardial infarction (MI)', ‘hypertension', ‘ventricular arrhythmias' and ‘diagnosis', to look for the most important and relevant articles concerning with the diagnostic approaches of hypertension, MI, and arrhythmias in general. Conclusion: Some ideal cardiac biochemical markers need to have not only high level of sensitivity but additionally high specificity to coronary infarction. The creatine kinase-MB, a reasonably certain cardiac marker, could be elevated in situations other than acute myocardial infarction. The ECG continues to be a cornerstone in the diagnosis of MI as well as need to be regularly duplicated, particularly if the first ECG is not analysis of MI. The diagnosing high blood pressure consist of 24-h ambulatory blood pressure monitoring (ABPM) as well as self-home) BP surveillance (SBPM) as optional methods for determining hypertensive patients. None of the current standards have actually yet consisted of ABPM or SBPM as essential devices for detecting hypertension, preferring instead to depend on standard workplace analyses tape-recorded by mercury sphygmomanometry.