Unilateral ureteral obstruction (UUO) is a popular speculative version of renal injury, associated with kidney drop. Throughout the time of UUO, nephron damage is started by a boosted intratubular hydrostatic pressure and also secondary ischemia. In the course of the disease, even more, general arbitrators of kidney injury are invited. Objective: Primary goal of this review was to highlight the complications following the Unilateral ureteral obstruction (UUO) and obstructive uropathy in general, as well as to discuss the therapeutic strategies for this urological condition. Material and method: We review the Published literature concerning unilateral ureteral obstruction (UUO) up to August, 2017. Search was conducted using electronic databases; Medline, and Embase. Search strategy through mentioned databases was performed using medical subject headings (MeSH) as following, “obstructive uropathy", “obstructive nephropathy", “Unilateral ureteral obstruction", “UUO". Furthermore, bibliographic of the articles were manually searched for having more relevant studies. Restriction to our search was applied to only English language published studies. Conclusion: Speculative UUO is an animal version of the human condition, which duplicates not only human-ureteral-tract-obstruction-induced kidney injury, it is largely held that CKD happens consequently of the procedure of damaging fibrosis. UUO is a well-described model of renal fibrosis and the mood of CKD occurrence while UUO persisting. Additionally, several crucial procedures in the pathogenesis of AKI as well as CKD, such as tubular cell injury, interstitial inflammation and fibrosis. Management approaches of UUO can be through several steps; first the diagnostic management which will indicate the need of the following two steps of treatment;  whether pharmacological, as rapamycin substantially undermined kidney interstitial damages in a UUO-induced rat version of renal fibrosis, suggesting that rapamycin could have the possibility to postpone the progression of the transformation of renal mesenchymal and kidney fibrosis of surgical treatment. .