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11876

Quantitative Morphometric Study of The Chorionic Villi in Hypertensive Mothers

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Last updated: 03 Jan 2025

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Abstract

Background: Several studies have reported that mothers with pregnancy induced hypertension or those suffering from hypertensive disorders have abnormalities in histological features of the placenta. The fetus connection with the mother is through chorionic villi. Besides several other histological features changes in the chorionic villi have also been reported. This lead to the reduced supply of the necessary nutritional elements for the fetus. The aim of the Study: The principal objective of this study was to evaluate morphometric changes in the placenta of expecting mothers have hypertensive disorders of pregnancy and women without any symptoms of hypertension. As the placenta is capillary-rich region and any physiological change can adversely affect the fetal health. Patients and Methods: In this study, a total of 84 expecting mothers were recruited. Among these 42 have hypertensive symptoms before pregnancy whereas the other 42 have their blood pressure in normal ranges. Among the 42 hypertensive women, only 13 met the study inclusion criteria,i.e., blood pressure in the range of 140/90 mmHg in the 30th week of the pregnancy. The quantitative morphometric parameters included shape and size of the placenta, damage to the blood vessels mainly in the chorionic villi and an overall number of blood vessels. Results: A comparative evaluation of placenta from the hypertensive and normotensive expecting mothers showed that blood vessels area in the hypertensive mothers was significantly reduced when compared to normotensive mothers, same holds from the blood vessels in the perimeter areas. These findings have important implications as far as the fetal development among hypertensive mothers is concerned. Conclusions: Higher blood pressure associated changes in the placenta are manifested in the form of several histological and morphological changes mainly in the chorionic villi structures involved in fulfilling nutritional requirements of the fetus.  

DOI

10.12816/0041535

Keywords

placenta, Chorionic villi, Hypertension, Pregnancy

Authors

First Name

Abdulrhman Saleh

Last Name

Dairi

MiddleName

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Affiliation

Medical Intern, Faculty of Medicine and Surgery, Umm Al-Qura University

Email

askdairi@gmail.com

City

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Orcid

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First Name

Wagih Gamal

Last Name

Elbarrany

MiddleName

-

Affiliation

Professor of Anatomy, Faculty of Medicine and Surgery, Umm Al-Qura University

Email

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City

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Orcid

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First Name

Amna Abdul Rahim

Last Name

Moulana

MiddleName

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Affiliation

Consultant of Anatomical Pathology, Maternity and Children's Hospital, Ministry of Health, Makkah, Saudi Arabia

Email

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City

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Orcid

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First Name

Ahmad Sami A Himayda

Last Name

Himayda

MiddleName

-

Affiliation

Medical Intern, Faculty of Medicine and Surgery, Umm Al-Qura University

Email

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City

-

Orcid

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First Name

Iyad M

Last Name

Hakeem

MiddleName

-

Affiliation

Medical Intern, Faculty of Medicine and Surgery, Umm Al-Qura University

Email

-

City

-

Orcid

-

Volume

69

Article Issue

4

Related Issue

2178

Issue Date

2017-10-01

Receive Date

2018-08-29

Publish Date

2017-10-01

Page Start

2,315

Page End

2,322

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_11876.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=11876

Order

22

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Quantitative Morphometric Study of The Chorionic Villi in Hypertensive Mothers

Details

Type

Article

Created At

22 Jan 2023