Background: Diabetes is an imperative risk factor for cardiac complications development. Cleome droserifolia (Cd) is used in Egyptian traditional medicine for treatment of diabetes mellitus. Aim: The aim of the present study was to measure the possible protective effects of ethanolic extract of Cd against cardiacmyopathy in Streptozotocin (STZ) induced diabetic rats. Materials and Methods: Experimental diabetes was induced by intrapritoneal injection with a single dose of STZ (45 mg/kgbw). Oral dose Cd extract was administered daily for four weeks (310 mg/kg bw). Results: Diabetic rats exhibited an increase in glucose level and lipid profile as well as cardiacpro-inflammatory, pro-apoptotic markers and oxidative stress, while a decrease was recorded in antioxidant enzymatic activities. On the other hand the administration of diabetic rats with Cdextract for four weeks resulted in a significant amelioration in the most of the parameters mentioned above when compared with diabetic rats. Conclusion: The data clearly indicated that the treatment with Cleome droserifolia exerts a therapeutic protective nature in cardiac complications due to diabetes by decreasing oxidative stress and cardiac damage which may be attributed to its antioxidative potential.