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11843

Oxidative Stress in Segmental Versus Non Segmental Vitiligo

Article

Last updated: 24 Dec 2024

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Abstract

Background: vitiligo is a coetaneous autoimmune disease, cosmetically non-acceptable to patients with higher Fitzpatrick skin type because of the contrast between lesional and non-lesional skin. Oxidative stress through H2O2 that is converted by superoxide dismutase (SOD) into H2O and super oxide anion (O.-) which affects directly on preopiomelanocortin (POMC) system in the epidermis of vitiligo patients which plays the key role in melanogenesis. Aim of the work: this study aimed to measure H2O2 in segmental vs. non-segmental vitiligo. This was done through colorimetric evaluation of H2O2 in the epidermis of patients with vitiligo and it was focused on the role of the oxidative stress in the pathogenesis of vitiligo. Patients and methods: this pilot study was included 30 patients recruited from the outpatient clinic of Dermatology and Venereology at Ain Shams University Hospital and outpatient clinic of Al Haud Al Marsoud Hospital. They were all suffered from vitiligo. Fifteen of them had non-segmental and the other 15 had segmental vitiligo. Each group was subdivided into active and stationary. The active disease was defined as appearance of a new lesion and/or extension of preexisting lesionsin less than one year. Results: there was a significant increase of H2O2 level in the lesional vs. non-lesional skin in all number of patients, NSV patients, NSs patients, NSa, and SVs, but not in SVa patients. The H2O2 raised in NSV patients when compared to SV patients. There was a non-significant rise of H2O2; also in patients with SVa. There was a significant increase in the epidermal H2O2 level in the NSV patients above that of SV patients. Conclusion: this study suggested that oxidative stress was present in both SV and NSV. This might open a window for several studies concerning the patients of SV and whether the oxidative stress is primary or secondary. Also whether these patients might benefit from antioxidant medications or not.

DOI

10.12816/0041075

Keywords

Oxidative Stress, segmental versus, non-segmental vitiligo, H2O2

Authors

First Name

Nader Fouad

Last Name

Ragab

MiddleName

-

Affiliation

Dermatology and Venereohiilogy Department, Faculty of Medicine - Ain Shams University

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First Name

Mahmoud Abdel Rahim

Last Name

Abdallah

MiddleName

-

Affiliation

Dermatology and Venereohiilogy Department, Faculty of Medicine - Ain Shams University

Email

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City

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Orcid

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First Name

Manal Louis

Last Name

Luka

MiddleName

-

Affiliation

Dermatology and Venereohiilogy Department, Faculty of Medicine - Ain Shams University

Email

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City

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Orcid

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First Name

Noha Sobhy

Last Name

Abd El Wahab

MiddleName

-

Affiliation

Dermatology and Venereohiilogy Department, Faculty of Medicine - Ain Shams University

Email

nahnoha_nonna@yahoo.com

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Orcid

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Volume

69

Article Issue

3

Related Issue

2170

Issue Date

2017-10-01

Receive Date

2018-08-28

Publish Date

2017-10-01

Page Start

2,159

Page End

2,164

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_11843.html

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https://ejhm.journals.ekb.eg/service?article_code=11843

Order

27

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Oxidative Stress in Segmental Versus Non Segmental Vitiligo

Details

Type

Article

Created At

22 Jan 2023