Aim of work: this study aimed assess the efficacy of radioembolization (Yttrium-90) therapy in Hepatocellular carcinoma (HCC) patients with portal vein thrombosis. Patients and methods: this study included 24 patients diagnosed with HCC and portal vein invasion to be treated with Transarterial Radioembolization (TARE). They were 17 males and 7 females. Patients received a single course of treatment. Results: tumor radiological response assessment revealed that the tumor was controlled in 92% of the patients. Complete response was observed in 21 % of the patients, partial response in 29 % of the patients, stable disease in 42 % of the patients and progressive disease in 8% of the patients. Conclusion: Yttrium-90 radioemblization appeared to be an effective, safe and feasible treatment option for patients with hepatocelluar carcinoma with portal vein invasion.