Background: Chronic Kidney Disease is a global public health issue, with increasing incidence. It consists wide spectrum of renal conditions that lead to progressive decline in renal function and abnormal GFR. Liver disorders are common among chronic kidney diseases. LFT's particularly play a vital role in the diagnosis and monitoring CKD patients. Currently, eGFR considered being the most valuable parameter for diagnosing CKD. But it has some limitations, it is not done routinely in apparently healthy people, secondly, GFR has different normal values for different ethnic groups so the formulae for calculating eGFR being used in west might not be applicable in eastern population and vice versa. Objectives: This study was carried out to compare hepatic enzymes of patients with different stages of chronic kidney disease. Materials and methods: A total of 257 persons were recruited. Cases were divided into two subgroups based on the glomerular filtration rate (GFR). Subgroup 1: 85 Cases had GFR <15, subgroup 2: 99 cases with GFR > 15 and Subgroup 3: 73 normal healthy controls. The hepato-renal profile was done for all cases and controls. Results: Hepatic transferases in the patients undergoing dialysis fell into the normal range. But the same enzymes showed a marked elevation in the patients with chronic kidney disease having non-invasive treatment. Alkaline phosphatase showed mark elevation for both groups A and B as compared to normal controls.