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11513

Role of Transarterial Chemoembolization (TACE) in Down Staging of Hepatocellular Carcinoma (HCC) before Liver Transplantation

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Last updated: 24 Dec 2024

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Abstract

Background: liver transplantation (LT) has emerged as the optimal treatment for cirrhotic patients with Hepatocellular carcinoma (HCC) because it cures both tumor and underlying cirrhosis. HCC could be downstaged or controlled by various anticancer therapies, which might bring them chance of undergoing a curative treatment such as LT. Aim of the Work: it was to evaluate the outcomes of HCC downstaged patients using transarterial hepatic chemoembolization (TACE) therapy to allow eligibility for liver transplantation. Patients and Methods: the study included all the cirrhotic patients who underwent TACE for downstaging of HCC to become eligible for liver transplantation at the period from 2008 to 2017 in Ain Shams Specialized Hospital. Al the patients underwent TACE to meet the Milan criteria for liver transplantation. Results: the etiology of cirrhosis and HCC in our patients was primarily Hepatitis C virus which is endemic in our country. All the cases were not eligible for liver transplantation because they were out of Milan criteria, therefore all the cases underwent TACE for downstaging of the tumor to be within the Milan criteria to become fit for liver transplantation. After undergoing TACE for downstaging, Patients underwent living donor liver transplantation, then they were followed up for detection of recurrence on the transplanted liver. Four of the twenty seven patients had recurrent HCC (14.8 %). Conclusion: successful down-staging of HCC by TACE can be achieved in the majority of carefully selected patients and is associated with excellent posttransplantation outcome.

DOI

10.21608/ejhm.2018.11513

Keywords

LT, HCC, TACE

Authors

First Name

Abdallah Lutfy Farouk

Last Name

Ahmed

MiddleName

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Affiliation

Radiology Departments, Faculty of Medicine, Ain Shams University

Email

dr.abdallahlutfy@hotmail.com

City

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Orcid

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First Name

Haytham Mohamed

Last Name

Nasser

MiddleName

-

Affiliation

Radiology Departments, Faculty of Medicine, Ain Shams University

Email

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City

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Orcid

-

First Name

Mohamed El-Gharieb

Last Name

Abo-Elmaaty

MiddleName

-

Affiliation

Radiology Departments, Faculty of Medicine, Ain Shams University

Email

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City

-

Orcid

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First Name

Iman Fawzy

Last Name

Montasser

MiddleName

-

Affiliation

Radiology Departments, Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

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Volume

72

Article Issue

11

Related Issue

2148

Issue Date

2018-07-01

Receive Date

2018-08-25

Publish Date

2018-07-01

Page Start

5,578

Page End

5,583

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_11513.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=11513

Order

10

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Transarterial Chemoembolization (TACE) in Down Staging of Hepatocellular Carcinoma (HCC) before Liver Transplantation

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Article

Created At

22 Jan 2023