Background: vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules and patches. Researchers suggested that vitiligo may arise from autoimmune (AI), genetic, oxidative stress or neural causes. Zinc (Zn) and copper (Cu) are trace elements that are required in minutely small doses. The unique process of keratinization and melanin formation is enzyme-dependent and therefore could be influenced by trace elements deficiencies or excesses as trace elements are involved in enzymatic activities and immunologic reactions. Aim of work: this study aimed to detect the levels and roles of serum Zn and Cu in the pathogenesis of vitiligo. Patients and methods: our study included 50 vitiligo patients and 50 apparently healthy controls. Age of study groups ranged from 15 to 60 years and both sexes. Serum Zn and Cu levels were measured in each study group. Results: serum Zn levels were statistically significant lower in both the studied groups, but in vitiligo group they were much lower than the control group. Serum Cu levels were statistically insignificant higher in vitiligo group than the control group. Conclusion: there is a relationship between vitiligo and serum Zn. Further studies are needed to obtain better knowledge about effect of the trace elements in vitiligo patients.