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Role of Systematic Steroids in Sepsis and Septic Shock Treatment Outcome: A Systematic Review

Article

Last updated: 03 Jan 2025

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Abstract

Introduction: The use of restorative corticosteroids in very ill patients with sepsis is disputable. This study aiming at evaluation of evidence supporting use of corticosteroids therapy for prevention of septic shock in patients with severe sepsis. Methods: The electronic search was conducted in Medline and Embase databases using specific search terms. The search resulted in 106 relevant articles. The primary screening for relevance of this articles lead to exclude of 101 titles and only 5 studies were finally included in this review. Results: The review included 5 double-blind randomized clinical trials, 4 of them were prospective, and one retrospective study. Overall sample size (n= 1157   patients) in the prospective studies and (n=328 patients) in the retrospective study. Mean age ranged from (50 to 65 years) in the prospective studies and it was 65 years in the retrospective study. Conclusions: This review could not support the evidence of using corticosteroids in the management of patients of sepsis especially those at risk for development of septic shock.

DOI

10.12816/0043830

Keywords

steroids, Sepsis, Septic shock, Management

Authors

First Name

Jumana Sahal

Last Name

Malibari

MiddleName

-

Affiliation

College of Medicine, Umm Al-Qura University, Saudi Arabia

Email

jumana.melebari@gmail.com

City

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Orcid

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Volume

70

Article Issue

4

Related Issue

2136

Issue Date

2018-01-01

Receive Date

2018-08-19

Publish Date

2018-01-01

Page Start

708

Page End

712

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_11417.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=11417

Order

30

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Systematic Steroids in Sepsis and Septic Shock Treatment Outcome: A Systematic Review

Details

Type

Article

Created At

22 Jan 2023