Aim of the work: this study was carried out to determine the prevalence and risk factors of the occurrence of gallstone disease among the Saudi Arabian population. Patients and methods: a retrospective survey was done among 100 patients with gallstone disease from November 2016 to March 2017 using a structured data collection tool. Results: The results showed that 60% of those with the disease were women, while only 40% were men and 29% belonged to age group 30-39 years old. Among the risk factors studied, there was a statistically significant association between the disease and fever and lipid profile, total cholesterol, LDL, and TAG (p-value,<.01). In addition to fever, majority of the patients also complained for right upper quadrant pain. Perhaps primary health care physicians should consider fever with right upper quadrant pain as warning signs for gallstone disease which should warrant more sensitive procedures like ultrasonography for early detection of the disease. Fundamental knowledge of gallstone disease is essential for clinicians so as proper management be offered to ailing patients.