Introduction: Pharmacotherapeutic treatment strategies of urinary tract infections (UTIs) in pregnancy needs legitimate diagnostic investigation and comprehensive knowledge of antimicrobial medications. This review aiming at obtaining the evidence about the effectiveness of antibiotic treatment for UTI among pregnant women that evaluated by included randomized controlled trials. Methods: An Electronic search was conducted in Medline and Researchgate databases using simple search terms include (Pregnan* AND Infection AND Treatment). The search of the literature, after exclusion of irrelevant, duplicated and review studies, revealed 8 studies met the inclusion criteria. Results:  Most of the included studies used cephalosporins family of antibiotics. The cure rate of ceftibuten was 95.2% compared to 90% in fosfomycin. A cure rate of 96% after treatment by ceftriaxone and 94% after administration of cephazolin were reported. When gentamycin plus ampicillin used for the treatment of UTIs a cure rate of 93% was reported. Conclusions: This review found high effectiveness and cure rate of the antibiotics used in treatment of UTIs, however the recurrence rate varied between studied antibiotics.  Nitrofurantoin and intravenous antibiotics reported very low recurrence rate in comparison to fosfomycin and cephazolin with a clinically significant recurrence rate.