Background: age-related changes of the face have been an area of intense interest and the focus of considerable researches. The facial skeleton and overlying soft tissue undergo a gradual transformation throughout the aging process and there are several consistent age-associated changes of the nose. Aim of the Work: this study aimed to evaluate the age related cellular and architectural changes of nasal tip support mechanisms, in correlation to its anthropometric measurements. Patients and Methods: this prospective study was conducted in Plastic and Reconstructive Surgery and Histology Departments, Ain-Shams University Hospitals, Cairo, Egypt. Forty-five patients were included in this study. They had undergone aesthetic rhinoplasty operations, 10 males (25%) and 30 females (75%) with mean age 35.42±15.15 years and age range 19–60 years. Results: LLC is the most nasal tip support mechanism affected by aging as every 1 year increase in age; correspond to weakness in LLC by percent -1.077followed by ULC, SC, SCA, IDA, ICA, NLA, and projection respectively (P value <0.001). Conclusion: aging patients present unique technical challenges in rhinoplasty that warrant a comprehensive approach to restore and preserve tip support. Recommendations: medial crural septal suture should be performed in all elderly patients undergoing aesthetic rhinoplasty, both to prevent further exaggeration of the already existed acute nasolabial angle and to maintain the nasal tip projection and rotation.