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11367

Efficacy of Intravenous Tenoxicam as an Analgesic during the First Stage of Labor: A Randomized Controlled Trial

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Last updated: 03 Jan 2025

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Abstract

Background: childbirth is one of the most painful events of a woman's life. The experience of labor pain is a complex, multidimensional response to sensory stimuli generated during parturition and its intensity can vary greatly. Unlike other acute and chronic pain experiences, labor pain is not associated with pathology, but with the most basic and fundamental of life's experiences Aim of the work: this work aimed to study the efficacy of intravenous tenoxicam for labor analgesia. Patient and methods: this was two-arm, randomized controlled trial. The first arm (Group T) represented subjects who received tenoxicam. The second arm (Group R) represented subjects who received routine analgesic pethidine and it is given at a dose of 50 mg diluted over 10 ml of normal saline. The parturient woman was given 3-4 cm of diluted pethidine whenever she has intolerable pain. Results: this study included 260 subjects that were allocated into two arms: tenoxicam arm (n=118) and pethidine arm (n=142) as the control group. Tenoxicam group included 118 subjects and the pethidine group included 142 subjects. Maternal age was 23.74 ± 3.76 in tenoxicam group vs 23.99 ± 3.5 in pethidine group. Gestational age was 39.04 ± 1.42 in tenoxicam group vs 38.93 ± 1.5 in pethidine group. Birth weight was 3.43 ± 0.26 in tenoxicam arm vs 3.41 ± 0.26 in pethidine arm, average fetal heart rate was 140.1 ± 17.12 in tenoxicam arm vs 138.1 ± 16.39 pethidine arm, cervical dilatation was 4.19 ± 0.77 in tenoxicam arm vs 4.25 ± 0.7 and interval to delivery was 5.89 ± 1.29 in tenoxicam arm vs 6.2 ± 1.62 in pethidine arm. Conclusion: tenoxicam (40 mg iv), a long acting NSAID that induces analgesia by inhibiting peripheral prostaglandin synthesis, reduced postpartum uterine contraction pain without apparent maternal or neonatal adverse effects. Furthermore, tenoxicam exhibits superior analgesic properties over the routinely used pethidine as labor analgesic. Further studies should evaluate analgesic effects vs side effects of iv tenoxicam as a function of dosage or as part of combination therapy with different opioid analgesics.

DOI

10.12816/0043812

Keywords

tenoxicam, labor analgesia

Authors

First Name

Hatem S.

Last Name

Shalaby

MiddleName

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Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Ain Shams University

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Orcid

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First Name

Hosam M.

Last Name

Hemada

MiddleName

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Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Ain Shams University

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Orcid

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First Name

Mohamed A.

Last Name

Faris

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Ain Shams University

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City

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Orcid

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Volume

70

Article Issue

4

Related Issue

2136

Issue Date

2018-01-01

Receive Date

2018-08-18

Publish Date

2018-01-01

Page Start

601

Page End

609

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_11367.html

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https://ejhm.journals.ekb.eg/service?article_code=11367

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Efficacy of Intravenous Tenoxicam as an Analgesic during the First Stage of Labor: A Randomized Controlled Trial

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Article

Created At

22 Jan 2023