Background: Osteoporosis is a worldwide health problem leading to an increased susceptibility to fractures and even more other complications. Awareness and perceptions of susceptibility and belief in the seriousness of a disease can help in its prevention and control. Objective: this study was aimed to evaluate knowledge and perceptions of osteoporosis among Saudi population from different country regions and different educational levels. Methodology: 986 participants from all over Saudi Arabia regions and the majority of them were from Taif governorate they were involved in a self- administered online questionnaire that was conducted in August, 2017 through the period to November, 2017 and was available online and easy to access to wide group of people, to evaluate the extent of knowledge about osteoporosis among Saudi population from those different regions of the country. Results: 986 participants from all over Saudi Arabia regions and the majority of them were from Taif governorate they were involved in a self- administered online questionnaire to evaluate the extent of knowledge about osteoporosis among Saudi population from those different regions of the country.The majority of the participants were aware of some knowledge about osteoporosis but female respondents were more knowledgeable in some very important points in this manner. Age was negatively correlated with the level of awareness though Awareness of osteoporosis was significantly different between educational groups. Conclusion: It is important to raise the awareness and knowledge of osteoporosis and its prevention measures as osteoporosis is a preventable disease among Saudi population. Saudi Ministry of health need to determine the population's knowledge of and attitudes towards osteoporosis to plan effective education programs to be able to avoid late complications and to safe highly cost methods of treating such a conditions.