Background: Coagulopathies in ICU are one of the most common complications in ICU. DIC is one of the most threatening coagulopathies in ICU.It is accompanied with high mortality rates in ICU.Early diagnosis of DIC is very important for early intervention for better prognosis.DIC is caused by several pathologies like sepsis, trauma, obstetric causes and malignancies. Aim of the Work: to compare between the sensitivity between fibrinogen/CRP ratio and FDP and D-dimer. Patients and Methods: After obtaining approval from the medical ethical committee at Ain Shams University, this observational prospective study was conducted at Ain Shams University Intensive Care Units. The study included 70 patients in Demerdash ICU after including patients with ISTH score ≥5.  2 samples were collected from each patient. Results: The results were in favor to the classical parameters of diagnosis of overt DIC in comparison with the new parameter of DIC. It showed that D-dimer and FDPs together were more sensitive than fibrinogen/CRP ratio. Conclusion: The D-dimer and FDP tests offered the best test panel in the diagnosis of DIC especially in overt DIC due to their high sensitivity.