Aim of the work: gastrointestinal stromal tumours (GISTs) are a type of mesenchymal tumours of the gastrointestinal (GI) tract. The tumour can originate anywhere from the oesophagus to the rectum, but most often comes from the stomach or small intestine. Despite the fact that GISTs are the most common mesenchymal neoplasms of the GI tract, they remain a diagnostic challenge because of the overlapping clinicopathologic features with GIST. Large GISTs are usually associated with complications such as gastrointestinal (GI) haemorrhage, GI obstruction, and bowel perforation. GISTs are predominantly found in people in their 60s, but a small population can develop it a younger age. Patient and methods: this was a report the case of a 65-years old male presented to our hospital with upper gastrointestinal bleeding. Results: vomiting and severe anaemia findings were detected in diagnostic image studies which suggested a gastric GIST without evidence of metastatic disease; therefore, totally tumour excision was performed. Cytologic and inmuno-histochemistry analysis confirmed diagnosis of GISTs.
Conclusion: the present case report highlighted the need of early recognition and appropriate investigation of gastrointestinal symptoms at all ages for ruling out  potential malignancy.