Background: Neonates with the maternal premature rupture of membranes are commonly encountered in the clinical practice. The condition has an important implication for the management of neonates, as it is associated with certain risks of morbidity and mortality. The management varies among the physicians. The study aimed at evaluating out the neonatal outcome of the existing condition with institutional practice. Methods: The study was conducted at King Khalid Hospital, Al Majmaah KSA from August 2016 to August 2017. Two hundred neonates born to mothers with premature rupture of membranes were evaluated, monitored and treated in neonatal unit. Septic screening was done in all the neonates and empiric antibiotics were started for all the neonates. Maternal risk factors were taken into consideration. Neonatal outcomes were considered in all cases. Results: There were 111 male and 89 female neonates. Most of the cases were term prom while 68 cases were pre-prom. Most commonly associated complication was feeding intolerance found in 16% of cases. Only two neonates had a positive blood culture for group B streptococci. Maternal high vaginal swab yield group B streptococci in 17 cases. Sepsis developed in three cases. One hundred and ninety eight neonates were discharged home while one patient died of severe sepsis. Conclusion: PROM is a common clinical entity that requires careful handling of the neonates to prevent the mortality and morbidity. With prompt treatment, the outcome can be significantly improved.