Background: It is observed that the adverse drug reactions are one of the many reasons contributing in the deterioration of health and wellbeing. Objectives: This study was carried out to list the numerous elements affecting the knowledge, attitude, and practice of pharmacists and pharmacy technicians towards pharmacovigilance and adverse drug reactions. Material and methods: A certain prepared questionnaire is performed over numerous pharmacies from the areas around in addition to the data collected from similar researches which performed the same method. Results: Based upon the findings of our study, we came to a vision of the superiority of pharmacists over pharmacy technicians when it comes to acknowledging how to deal with pharmacovigilance and adverse drug reactions. Conclusion: Pharmacists are more knowledgeable when it comes to ADRs than pharmacy technicians, yet both of them needs to go under training for enhancing their knowledge.