Background: BCG is a live attenuated vaccine. It has been used to prevent tuberculosis since 1921.BCG is widely used, it is estimated that 100 million newborns are receiving it yearly. It also has a low incidence of serious adverse reactions and considered safe. However, few severe complications have been reported despite its wide use.Adverse reactions of BCG vaccination included suppurative lymphadenitis, localized abscess or a combination of both. In addition to them there was disseminated BCG-itis, which is life threatening, but very rare. Aim of the work: this study reported a case of a five-month-old child with BCG-itis which presented to us. Patient and method: left axillary swelling was increased in size with bloody discharge and associated fever. Family history of IL12 deficiency was also noted.  Results: diagnosis was made by AFB and PCR. The child responded well to anti-mycobacterial treatment. Because neonatal BCG vaccine is included in many standard vaccination schedules around the world, it is extremely difficult to avoid administering it to infants who might have PID. Conclusion: it is important to recognize BCG adverse reactions because they can be the first clue to diagnosing immunodeficiencies.