Background: Using recombinant tissue plasminogen activator (rt-PA) during the first 3 h up to 6 h of stroke was allowed to reduce the poor functional consequences of stroke.
Objectives: assess the effects of intravenous dosage of rt-PA during the first 6 h after on early and late outcomes of acute ischemic stroke (AIS).
Methods: all studies regarding the intravenous rt-PA given within 6 h of onset of acute ischemic stroke up to 2016 were searched the outcomes, and the mortality rates were evaluated at the final follow up.
Results: There was a significant increase in functional outcome by using IV-tPA significantly (p <0.01).
 A significant decrease was found in intracranial hemorrhage in the patients treated with IV-tPA. The mortality rates were significantly decreased at the end of the follow up period in patients treated with IV-tPA.
Conclusion: The study indicated that using intravenous rt-PA could increase the number of living patients favorable outcome, less disabilities and intracranial hemorrhage among acute ischemic stroke patients during the first 6 hours.