Background: Myrtle leaves extract (ME) has many antioxidants that protect against oxidative stress. The current study was conducted to determine whether ME can possibly exert hepatoprotective and antioxidant activity against monosodium glutamate (MSG) and acrylamide (ACR) that induced toxicity in rats. Objectives: Our experiment was carried out to examine theeffect of Myrtus communisextractagainst hepatotoxicity stimulated by monosodium glutamate (MSG) and acrylamide (ACR) in male rats. Materials and methods:  Rats were randomly assigned into eight groups, containing six each as following: group 1: rats received dist. water (control); group 2: rats were orally administered myrtle extract (ME) (300mg/kg b w) daily for 7 wks.; groups 3, 4 and 5: rats were orally administered MSG (100mg/kg b w), ACR (20mg/kg b w) and (MSG + ACR) respectively daily for 6 wks. ; groups 6 ,7 and 8:rats were orally administered ME daily for seven days alone then associated with MSG or with ACR or with (MSG+ACR) respectively for 6 wks. Results: Our results proved that the treatment with MSG and/ or ACR resulted in a significant rise in TL, TC, TG, LDL-C, ALT, AST, ALP, GGT, TB and MDA. However, marked reduction in HDL-C, TP, Alb, GSH, TAC, SOD, CAT and GSH-Px. On the other side, the administration of ME improved the deviations resulted from MSG and/or ACR as confirmed by the marked improvement of antioxidants. Conclusion: It is concluded that ME could protect the liver against damage induced by MSG and ACR.