Background: Non-alcoholic fatty liver sickness (NAFLD) is a variety of liver pathological conditions that intensely related to other chronic diseases including obesity and diabetes. Objectives: Systematically evaluating the role of lifestyle interventions on reducing the activity of NAFLD. Methods: Collecting all the studies regarding the effects of changing the diet, exercise or combination of both on the activity or markers of NAFLD during the period from 2006 to 2017. Results: Database searches returned 122 citations with 92 included in more than one search then the final studied which include in this study was 19 articles. Five articles studied the effects of a combination of dietary and exercise interventions, four of these articles showed positive results regarding the Dietetic Association (ADA) Quality Criteria Checklist, while only one article showed a neutral results, i.e. 80.0% of the articles showed a positive effect of the combination of diet and exercise on the effect of NAFLD patients. Conclusion: This review showed that the combination of healthy life interventions, including exercise and health diet, are effective in reducing the activity of NAFLD and could result in complete reversal of the condition. Thus NAFLD patients are advised to lose about 10% of their weight and engaging in regular exercises for 5 days per week.