Background: Over the last decade skull base surgery has been significantly progressed because of the obvious improvements in imaging, anesthetic, surgical techniques as well as the advancement of microsurgical instruments. However, the anatomical complexity of skull base makes dealing with lesions in such area a “surgical challenge". That's why looking for alternative methods is always needed. Meanwhile there have been significant advances in the field of cranial base surgery with the help of endoscopic techniques to manage such lesions. Objective: To demonstrate the value of endoscope-assisted microsurgical technique for resection of skull base tumors. Patients and Methods: Twenty patients had skull base tumors were operated through Endoscopic-assisted microscopic skull base surgery technique at Al-Azhar University & Mansoura International Hospital between 2015 to 2017 using a rigid endoscope for inspection of tumor boundaries and neighboring vascularity in addition to confirm the extent of resection. Tumor resection was tried in all cases. Intra-operative resection rate and post-operative radiological outcomes were assessed. Results: Total resection was done in 10 patients (50%). Subtotal resection was done in the other 10 cases due to excessive bleeding and adhesions of the tumors with vascular structures. Conclusion: Endoscopic-assisted microsurgical approach is a reliable, safe and effective option for adequate surgical resection of skull base tumors. The technique allowed proper inspection of the tumor relations and vascularity, detection of any residual portions, providing better chance for gross total resection with minimal tissue damage or vascular injury as well as convenient clinical outcome.