Background: Prematurity is a major obstetric complication that affects infants' growth and development, and is also a big cause of infant mortality across the world. Prematurity is associated with certain risk factors, such as age extremes, mother's diet and health, multiple pregnancies, maternal infections, maternal smoking, inadequate follow-up, and insufficient management of maternal chronic diseases. Aim: In this study we aim to study knowledge and attitude of pregnant women toward the prematurity causes and complication. Methodology: We conducted a cross-sectional study, of 2470 women who presented in king Abdulaziz University, Jeddah, Saudi Arabia from April 2017 to December Conclusion: We noted that although most mothers were aware of the positive impact on their health by regular follow-up visits to physician, many of them were not largely informed of the common associated risk factors. Better prenatal counselling can help create better awareness.