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Effect of Psidium guajava leaf extract, glibenclamide and their combination on rat model of diabetes induced by streptozotocin

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Last updated: 03 Jan 2025

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Abstract

Aim: The present aim is to evaluate the anti-diabetic effect of aqueous extract of guava (Psidium guajava) leaf using rat model of diabetes induced by streptozotocin. In addition, the effect of this extract on liver and kidney functions induced in rat model of diabetes were investigated.
Material and Methods: Rats were divided randomly into: control group, rat model of diabetes induced by streptozotocin, rat model of diabetes treated with aqueous extract of guava leaf, rat model of diabetes treated with glibenclamide and rat model of diabetes treated with aqueous extract of guava leaf plus glibenclamide. Result: In the present rat model of diabetes a significant decrease in the serum insulin level and a significant increase in glucose level were detected. Streptozotocin induced a significant increase in the activities of AST, ALT, ALP and a significant increase in the levels of bilirubin, urea, creatinine and uric acid. In addition histopathological and immunological changes were detected in the pancreatic tissue. The present data revealed that aqueous extract of guava leaf improved the reduced insulin level and the high glucose level induced by streptozotocin. This was associated with an improvement in the changes in the liver and kidney functions. Loss of body weight gain induced by streptozotocin was alleviated by guava leaf extract, glibenclamide or both. Conclusion: According to the present findings it could be concluded that the aqueous extract of guava leaf has a potent anti-hyperglycemic effect on rat model of diabetes induced by streptozotocin with hepatic and renal protective effects.

DOI

10.21608/ejhm.2018.9789

Keywords

hypoglycemic, streptozotocin, Psidium guajava, Liver functions, kidney functions, Rats

Authors

First Name

Shadia Ali

Last Name

Radwan

MiddleName

-

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

Email

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Orcid

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First Name

Omnia Nasr Abdelrhman

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

Email

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City

-

Orcid

-

First Name

Yasser A.

Last Name

Khadrawy

MiddleName

-

Affiliation

Department of Medical Physiology, Medical Division, National Research Center

Email

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City

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Orcid

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First Name

Gamal Abdel-Aty

Last Name

Hafez

MiddleName

-

Affiliation

Department of pathology, Faculty of medicine- Suez Canal University

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Orcid

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Volume

72

Article Issue

6

Related Issue

1884

Issue Date

2018-07-01

Receive Date

2018-07-28

Publish Date

2018-07-01

Page Start

4,610

Page End

4,619

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 6_Pages 4610-4619.pdf

PDF . 260.2kB

Link

https://ejhm.journals.ekb.eg/article_9789.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9789

Order

6

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Psidium guajava leaf extract, glibenclamide and their combination on rat model of diabetes induced by streptozotocin

Details

Type

Article

Created At

22 Jan 2023