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9496

Assessment of Vitamin D Status In Patients With Essential Hypertension

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Last updated: 24 Dec 2024

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Abstract

Background: There is close relationship between Vit D deficiency and hypertension. It was found that Vit D is potent inhibitor of Renin Aldosterone Angiotensin System (RAAS) which is the main mechanism responsible for development of hypertension. Aim of The Work: To assess the role of vitamin D deficiency in the development of essential hypertension and aggravation of its vascular complications. Subjects and Methods: This study was conducted on 80 individuals. Individuals were divided into two groups: Group 1: comprising 60 patients with essential hypertension. Group 2: comprising 20 healthy individuals. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Liver and renal function tests, fasting and PP blood glucose, CBC, lipid profile, serum vitamin D (25hydroxycholecalciferol), serum Ca & Ph. Doppler study on carotid artery to assess vascular complications and Echocardiography to assess ventricular mass was done. Results: There was statistically significant decrease (p value <0.05) in vitamin D in patients group in comparison to control group. There was highly statistically significant increase (p value <0.001) in intimal thickness and left ventricular mass in patients with low vitamin D level in comparison to patients with normal vitamin D level. In the patient group, 6 patients (10%) were suffering from vitamin D deficiency while 30 (50%) were suffered from vitamin D insufficiency while 24 (35%) show normal levels of vitamin D. Interestingly, intimal thickness and ventricular mass were significantly higher in patients with essential hypertension with low vitamin D than those with normal vitamin D levels. Conclusions: Vitamin D deficiency occurs in the majority of essential hypertension patients and therefore decreased serum vitamin D levels is considered an additional risk factor for cardiovascular morbidity and mortality.

DOI

10.21608/ejhm.2018.9496

Keywords

Vitamin D Status, Essential hypertension

Authors

First Name

Sameh Ahmad

Last Name

Abd-El Kader

MiddleName

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Affiliation

Internal Medicine Department

Email

samehahmed806@yahoo.com

City

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Orcid

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First Name

Youssef Khalel

Last Name

Ahmad

MiddleName

-

Affiliation

Internal Medicine Department

Email

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City

-

Orcid

-

First Name

Esam Mohamed

Last Name

El-Ghamry

MiddleName

-

Affiliation

Internal Medicine Department

Email

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City

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Orcid

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First Name

Salwa

Last Name

Tawfik

MiddleName

-

Affiliation

Internal Medicine, National Research Center

Email

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City

-

Orcid

-

First Name

Wael Mohamed

Last Name

Atia

MiddleName

-

Affiliation

Cardiology Department

Email

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City

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Orcid

-

First Name

Mohammad Mohammad

Last Name

Keder

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Al-Azhar University

Email

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City

-

Orcid

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Volume

72

Article Issue

5

Related Issue

1829

Issue Date

2018-07-01

Receive Date

2018-04-03

Publish Date

2018-07-01

Page Start

4,434

Page End

4,438

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_9496.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9496

Order

5

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Assessment of Vitamin D Status In Patients With Essential Hypertension

Details

Type

Article

Created At

22 Jan 2023