Introduction: Around 10% of live births globally require immediate intervention, and 4 million neonatal deaths happen in a year, where one fourth of them are due to asphyxia. Regular respiration may fail to achieve spontaneously in about ten percent of live births, with one percent of cases needing resuscitation with chest compressions, and about 0.06% needing epinephrine. The target in neonatal resuscitation is to achieve sufficient functional residual capacity, while avoiding pulmonary damage, and to optimize the tissue delivery of oxygen without causing toxicity
Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: neonatal asphyxia, neonatal resuscitation, neonatal intensive care, respiratory distress syndrome, complications of prematurity, oxygen therapy, neonatal ventilation
Aim: In this review, we aim to study the various approach taken to provide immediate resuscitation to neonates with respect to respiratory distress.   
Conclusion: With advancing research, physicians should have more devices to decrease the mortality rates among infants. We also need more research to establish best recommendations and guidelines on the use of best interventions especially in clinical setting with limited resources.