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9294

A Randomized Trial of Combined Letrozole with Metformin Versus Clomiphene Citrate with Metformin in Polycystic Ovary (PCOS) patients

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Last updated: 03 Jan 2025

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Abstract

Background: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of anovulatory infertility. Currently, clomiphene citrate (CC) is considered the first-line therapy for ovulation induction for women with PCOS and infertility. Aromatase inhibitors (AIs) have been introduced as a new treatment option that could challenge CC for ovulation induction. Aim of the Work: The present study was designed to compare the efficacy of combined aromatase inhibitor (Letrozole) with metformin versus CC with metformin in PCOS patients. Patients and Methods: This study was done on 100 documented PCOS cases. They were divided into two groups, The 1st group received CC 50 mg twice daily from the 3rd day of cycle for 5 days and repeated for 3 cycles with metformin 500 mg 3 times daily as an adjunct with CC and continued for 3 cycles. The 2nd group received aromatase inhibitor (Letrozole) 2.5 mg twice daily from 3rd day of cycle for 5 days and repeated for 3 cycles with metformin 500 mg 3 times daily as an adjunct with letrozole and continued for 3 cycles. These cases were followed up for three cycles by transvaginal ultrasound folliculometry to document ovulation (size and number of follicles). Results: The results of the present study revealed both lines of treatment were effective in treatment of PCOS patients, with slight favorability in letrozole group but without statistically significant difference founded between CC group and letrozole group as regard ovulation rate, number of follicles at the end of first, second or third cycles, or as regard the diameter of follicles, i.e., both regimens showed efficacy to the same extent. Conclusion: both CC and letrozole are equally effective in treatment of infertility in PCOS patients, when combined with metformin treatment.

DOI

10.21608/ejhm.2018.9294

Keywords

PCOs, Clomiphene citrate, Letrozole, Metformin

Authors

First Name

Fahd

Last Name

El Omda

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine Al Azhar University

Email

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City

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Orcid

-

First Name

Ahmed

Last Name

Abd El Fattah

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine Al Azhar University

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Hashish

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine Al Azhar University

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Khalil

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine Al Azhar University

Email

-

City

-

Orcid

-

Volume

72

Article Issue

4

Related Issue

1779

Issue Date

2018-07-01

Receive Date

2018-05-24

Publish Date

2018-07-01

Page Start

4,382

Page End

4,388

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 4_Pages 4382-4388.pdf

PDF . 209.1kB

Link

https://ejhm.journals.ekb.eg/article_9294.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9294

Order

26

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

A Randomized Trial of Combined Letrozole with Metformin Versus Clomiphene Citrate with Metformin in Polycystic Ovary (PCOS) patients

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Article

Created At

22 Jan 2023