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9138

Intracytoplasmic Sperm Injection Outcome in Patient at Risk of Poor Responder Using Mild Ovarian Stimulation Protocol versus Short Gonadotropin Releasing Hormone Agonist Protocol

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Last updated: 24 Dec 2024

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Abstract

Background: Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition for both clinician and patient, due to its poor prognosis in terms of pregnancies and live births. Although in the literature a large number of papers have been published in which many stimulation protocols suggested should be considered as the best for these women, however, no conclusive results have been reached. Aim of the Work: To evaluate ICSI outcome in patient at risk of poor responder using mild ovarian stimulation protocol versus short gonadotropins releasing hormone agonist protocol. Patients and Methods: This randomized controlled study was conducted on one hundred patients, complaining of infertility at risk of poor responders, patients with at least two of the criteria specific for poor responders at assisted reproductive technology unit, international Islamic center for population studies and research, Alazhar University, Cairo, Egypt, between august 2016 and august 2017. Results: Statistically significant differences were found in the Endometrial thickness, E2 at day of HCG, No. of dominant follicles at day of HCG, Number of retrieved oocyte, fertilization rate, Embryo number, Number of transferred embryos, Pregnancy rate and cost p-value 0.029, 0.036, 0.007, 0.027, 0.048, 0.019, 0.046, 0.044 ,0.001 respectively. Conclusion: ICSI outcome was evaluated in patients at risk of poor responders using short Gonadotropin releasing hormone agonist versus mild ovarian stimulation protocol (clomiphene citrate); showing that short Gonadotropin releasing hormone agonist should be preferred in these patients.

DOI

10.21608/ejhm.2018.9138

Keywords

Sperm Injection Outcome, Poor Responder, Mild Ovarian Stimulation, Short Gonadotropin Releasing Hormone

Authors

First Name

Amr M.

Last Name

Elerasy

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine – Al-Azhar University

Email

amroerasy@yahoo.com

City

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Orcid

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First Name

Mohamed S.

Last Name

Hasanien

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine – Al-Azhar University

Email

-

City

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Orcid

-

First Name

Shoukry A.

Last Name

Elawdy

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine – Al-Azhar University

Email

-

City

-

Orcid

-

Volume

72

Article Issue

3

Related Issue

1778

Issue Date

2018-07-01

Receive Date

2018-07-15

Publish Date

2018-07-01

Page Start

4,194

Page End

4,199

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 3_Pages 4194-4199.pdf

PDF . 323.0kB

Link

https://ejhm.journals.ekb.eg/article_9138.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9138

Order

26

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Intracytoplasmic Sperm Injection Outcome in Patient at Risk of Poor Responder Using Mild Ovarian Stimulation Protocol versus Short Gonadotropin Releasing Hormone Agonist Protocol

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Article

Created At

22 Jan 2023