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9131

Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer

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Last updated: 03 Jan 2025

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Abstract

Background: Exosomes are microvesicles that are recently discovered in intercellular communication especially between tumor cells as lung cancer that are important for tumor development and progression. Objectives: Examine the diagnostic role of serum exosomal LncRNA in lung cancer among Egyptian population.
Methods: Lung cancer characteristic exosomal RNA-based biomarker Lnc-RNA-RP11-510M2.10 was selected based on bioinformatic methods, followed by RT-qPCR validation of their expression in serum of 20 patients with lung cancer and 10 healthy volunteers.
Results: serum exosomal Lnc-RNA-RP11-510M2.10 showed a significant negative association with lung cancer patients in comparison to patients with healthy persons (p<0.001).
Conclusion: Lnc-RNA-RP11-510M2.10 could be used as diagnostic and prognostic biomarker tools for lung cancer.

DOI

10.21608/ejhm.2018.9131

Keywords

Lung Cancer, Exosomal RNA extraction, Lnc-RNA-RP11-510M2.10

Authors

First Name

Fawzia Khalil1, Hanan H. Shehata1, Nehad Osman2, Omar Abdel-Rahman3,

Last Name

Marwa Ali1 and Ghada Mohamed1

MiddleName

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Affiliation

1 Medical Biochemistry and Molecular Biology Department, 2 Pulmonary Medicine Department, Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine –Ain Shams University

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Volume

72

Article Issue

3

Related Issue

1778

Issue Date

2018-07-01

Receive Date

2018-07-15

Publish Date

2018-07-01

Page Start

4,148

Page End

4,153

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 3_Pages 4148-4153.pdf

PDF . 360.2kB

Link

https://ejhm.journals.ekb.eg/article_9131.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9131

Order

19

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer

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Article

Created At

22 Jan 2023