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Expression of micro RNA-9 in Patients with Acute Myeloid Leukemia and its Impact on Treatment Strategy

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Last updated: 24 Dec 2024

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Abstract

Background: Acute myeloid leukemia (AML) is a malignant disorder of hematopoietic tissue. It is one of the most common malignancies in adults. It is characterized by its heterogeneous and complex nature that includes chromosomal, genetic and epigenetic abnormalities. MicroRNAs have been described to be one of the epigenetic regulators in AML.
Objective: The present study focused on measuring expression levels of miR-9 in de novo AML patients. 30 bone marrow samples were collected from patients attending at Hematology and Oncology Unit of Aldemerdash Hospitals.MiR-9 expression levels were measured using real time PCR. These expression levels were compared to 30 adult healthy volunteers.
Patients and Methods: The present study was carried out in medical oncology and Clinical Pathology Departments of Ain Shams University and National Research Centre, Egypt during the period between September 2017 and April 2018.
Results: Statistical analysis of the results showed that miR-9 was significantly down regulated in AML patients in comparison to controls. It is also significantly correlated to platelet count. Regarding diagnostic performance, this study showed that miR-9 has weak diagnostic performance but regarding screening function, it has perfect sensitivity but weak specificity so it can be used as an excluding test.
Conclusion: This study showed reduction of miR-9 in bone marrow of AML patients and opened the horizon for future studies on diagnostic and screening performance of miR-9 to be performed on larger scale and different ethnic groups.

DOI

10.21608/ejhm.2018.9093

Keywords

Leukemia, myeloid, Acute, miR-9, treatment outcome

Authors

First Name

1Mona A. Ismail, 2Hanaa R.M. Attia, 1Mona H.I. Farag, 1Dalia A.D. El Dine Salem,

Last Name

1Mysra S. Youssef

MiddleName

-

Affiliation

1Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, 2Department of Clinical Pathology, Medical Research Division, National Research Centre

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Volume

72

Article Issue

2

Related Issue

1774

Issue Date

2018-07-01

Receive Date

2018-07-14

Publish Date

2018-07-01

Page Start

4,026

Page End

4,033

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 2_Pages 4026-4033.pdf

PDF . 469.5kB

Link

https://ejhm.journals.ekb.eg/article_9093.html

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https://ejhm.journals.ekb.eg/service?article_code=9093

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28

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Expression of micro RNA-9 in Patients with Acute Myeloid Leukemia and its Impact on Treatment Strategy

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Article

Created At

22 Jan 2023