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Role Of Insulin Like Growth Factor in Polycystic Ovary Syndrome

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Last updated: 24 Dec 2024

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Abstract

Objectives: The polycystic ovary syndrome (PCOS) is conventionally defined as a combination of hyperandrogenism and anovulation with polycystic ovaries. Insulin-like growth factor I (IGF-I) is a 70 aa polypeptide hormone with endocrine, paracrine, and autocrine effects. it is now established that the ovary is a site of IGF-I gene expression and reception. However, this huge amount of data could be somehow distractive since different species may produce distinct IGFs (or their relative binding proteins and receptors) at different stages of follicular development.
Objective: The aim of this work was to determine the serum level of IGF-I to evaluate its role in PCOS. Subjects and Methods: Twenty-five infertile women with PCOS diagnosed by ultrasound examination and a history of oligomenorrhea, hirsutism and obesity were studied. Serum levels of insulin-like growth factor-1 (IGF-1) and hormonal profile were measured. Fifteen healthy and fertile women with regular menstrual cycles served as a comparison group.
Results: The serum levels of IGF-I were significantly elevated in women with PCOS compared with control and there was positive correlation between IGF-I from one side and each of BMI, W/H ratio, LH, LH/FSH ratio, TSN, T/SHBG ratio, right and left ovarian volumes. On the other side, IGF-I was inversely correlated with SHBG, right and left uterine artery PI and RI.
Conclusion: The significant finding of this study is that PCOS patients have increased circulating IGF-I levels than healthy controls and it can be used as a biochemical marker for PCOS.

DOI

10.21608/ejhm.2018.9088

Keywords

Insulin-like growth factor, Polycystic ovary syndrome, Hormonal profile

Authors

First Name

Magdi A. Laban1, Tarek A. Shemais2, Ehab Mohamed Elhelw3 and

Last Name

Ahmed R. El-Hassanin2

MiddleName

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Affiliation

1Department of Medical Biochemistry, Faculty of Medicine, Cairo, 2Department of Medical Biochemistry, Faculty of Medicine, Damietta, 3Department of Obstetrics and Gynecology, Faculty of Medicine, Damietta, Al-Azhar university, Egypt.

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Volume

72

Article Issue

2

Related Issue

1774

Issue Date

2018-07-01

Receive Date

2018-07-14

Publish Date

2018-07-01

Page Start

4,005

Page End

4,011

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 2_Pages 4005-4011.pdf

PDF . 467.2kB

Link

https://ejhm.journals.ekb.eg/article_9088.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9088

Order

24

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role Of Insulin Like Growth Factor in Polycystic Ovary Syndrome

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Article

Created At

22 Jan 2023